Philosophers of science turned to historical case studies in part in response to Thomas Kuhn's insistence that such studies can transform the philosophy of science. In this issue Joseph Pitt argues that the power of case studies to instruct us about scientific methodology and epistemology depends on prior philosophical commitments, without which case studies are not philosophically useful. Here I reply to Pitt, demonstrating that case studies, properly deployed, illustrate styles of scientific work and modes of argumentation that are not (...) well handled by currently standard philosophical analyses. I illustrate these claims with exemplary findings from case studies dealing with exploratory experimentation and with interdisciplinary cooperation across sciences to yield multiple independent means of access to theoretical entities. The latter cases provide examples of ways that scientists support claims about theoretical entities that are not available in work performed within a single discipline. They also illustrate means of correcting systematic biases that stem from the commitments of each discipline taken separately. These findings illustrate the transformative power of case study methods, allow us to escape from the horns of Pitt's "dilemma of case studies," and vindicate some of the post-Kuhn uses to which case studies have been put. (shrink)

This study is a phenomenological inquiry into several relatively unexplored phenomena, including certain key methodological issues. It seeks to elicit and explicate the grounds of free-fantasy variation, which Husserl insists contains his “fundamental methodological insight” since it articulates “the fundamental form of all particular transcendental methods…” In the course of pursuing the full sense of this method and its grounds, the essay also uncovers the origins and eventual presence of “self” and explores the multiple connections among self, mental life, embodiment (...) and the surrounding world. To that end, it is necessary to take seriously Husserl’s otherwise odd declaration that “‘feigning’ [‘Fiktion’] makes up the vital element of phenomenology as of every other eidetic science…”, and thus that every philosopher must “fertilize” his or her “fantasy” through works of art and history as well as other areas and practices of human life. The essay offers an in-depth probing of several striking but largely unexplored phenomena: exemplifying and possibilizing, and concludes with an exploration of one of the most pervasive themes in phenomenological inquiry: intersubjectivity. (shrink)

Zen and Japanese Culture is one of the twentieth century's leading works on Zen, and a valuable source for those wishing to understand its concepts in the context of Japanese life and art. In simple, often poetic, language, Daisetz Suzuki describes his conception of Zen and its historical evolution. He connects Zen to the philosophy of the samurai, and subtly portrays the relationship between Zen and swordsmanship, haiku, tea ceremonies, and the Japanese love of nature. Suzuki's contemplative work is enhanced (...) by anecdotes, poetry, and illustrations showing silk screens, calligraphy, and examples of architecture. Since its original publication in 1938, this important work has played a major role in shaping conceptions of Zen's influence on Japanese traditional arts. Richard Jaffe's introduction acquaints a new generation of readers with Suzuki's life and career in both Japan and America. Jaffe discusses how Zen and Japanese Culture was received upon its first publication and analyzes the book in light of contemporary criticism, especially by scholars of Japanese Buddhism. (shrink)

Autonomy has been central to moral and political philosophy for millenia, and has been positioned as a critical aspect of both justice and wellbeing. Research in psychology supports this position, providing empirical evidence that autonomy is critical to motivation, personal growth and psychological wellness. Responsible AI will require an understanding of, and ability to effectively design for, human autonomy (rather than just machine autonomy) if it is to genuinely benefit humanity. Yet the effects on human autonomy of digital experiences are (...) neither straightforward nor consistent, and are complicated by commercial interests and tensions around compulsive overuse. This multi-layered reality requires an analysis that is itself multidimensional and that takes into account human experience at various levels of resolution. We borrow from HCI and psychological research to apply a model (“METUX”) that identifies six distinct spheres of technology experience. We demonstrate the value of the model for understanding human autonomy in a technology ethics context at multiple levels by applying it to the real-world case study of an AI-enhanced video recommender system. In the process we argue for the following three claims: 1) There are autonomy-related consequences to algorithms representing the interests of third parties, and they are not impartial and rational extensions of the self, as is often perceived; 2) Designing for autonomy is an ethical imperative critical to the future design of responsible AI; and 3) Autonomy-support must be analysed from at least six spheres of experience in order to approriately capture contradictory and downstream effects. (shrink)

In this article, I distinguish two models of personal integrity. The first, wholeheartedness, regards harmonious unity of the self as psychologically healthy and volitional consistency as ethically ideal. I argue that it does so at the substantial cost of framing ambivalence and conflict as defects of character and action. To avoid these consequences, I propose an alternate ideal of humility that construes the self as multiple and precarious and celebrates experiences of loss and transformation through which learning, growth, innovation, and (...) dynamic relationship become possible. This ideal not only sustains prospects for integrity but is more suitable than wholeheartedness for recognizing practices of contestation, such as those involving potentially destabilizing encounters with difference that is common within pluralistic societies, as vital for rich, well-lived lives. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

A letter to The Times of London, May 9, 1992 protesting the Cambridge University proposal to award an honorary degree to M. Jacques Derrida.

Richard M.Gale reviewed my book in Notre Dame Philosophical Reviews in May 2009. The overall conclusion of my reply is that although Gale repeatedly claims that the book is defective, his review has not identified any genuine defects.

Is the societal-level of analysis sufficient today to understand the values of those in the global workforce? Or are individual-level analyses more appropriate for assessing the influence of values on ethical behaviors across country workforces? Using multi-level analyses for a 48-society sample, we test the utility of both the societal-level and individual-level dimensions of collectivism and individualism values for predicting ethical behaviors of business professionals. Our values-based behavioral analysis indicates that values at the individual-level make a more significant contribution to (...) explaining variance in ethical behaviors than do values at the societal-level. Implicitly, our findings question the soundness of using societal-level values measures. Implications for international business research are discussed. (shrink)

I try to show that Richard Rorty, although is not a moral philosopher like Kant, nerveless, has moral philosophy that it must be taken seriously. Rorty has not engaged with moral philosophy in the systematic manner common among leading modern and contemporary moral philosophers. This paper has two parts: first part, in briefly, is concerned with principles of his philosophy such as anti-essentialism, Darwinism, Freudism, and historicism. second part, will be a long and detailed, considers many moral themes in (...) Rorty''''''''s thought such as critique of Kantian morality, solidarity, moral progress, cruelty and concept of other, etc. subsequently, we will try to answer question of the article (namely, has Rorty a moral philosophy?). (shrink)

Investigation of neural and cognitive processes underlying individual variation in moral preferences is underway, with notable similarities emerging between moral- and risk-based decision-making. Here we specifically assessed moral distributive justice preferences and non-moral financial gambling preferences in the same individuals, and report an association between these seemingly disparate forms of decision-making. Moreover, we find this association between distributive justice and risky decision-making exists primarily when the latter is assessed with the Iowa Gambling Task. These findings are consistent with neuroimaging studies (...) of brain function during moral and risky decision-making. This research also constitutes the first replication of a novel experimental measure of distributive justice decision-making, for which individual variation in performance was found. Further examination of decision-making processes across different contexts may lead to an improved understanding of the factors affecting moral behaviour. (shrink)

Can we find a phenomenological basis for the ethical 'ought'? This essay addresses this question through a reflection on Husserl's fifth Meditation. In the fifth Meditation Husserl endeavors to show the manner in which I constitute the other through an associative pairing of the other with my own subjectivity. This essay argues that this same associative pairing forces me to acknowledge the other as a person of intrinsic worth insofar as I recognize myself as one. Having acknowledged the intrinsic worth (...) of the other in this way, I cannot but acknowledge my obligation to treat the other as I would like to be treated. Thus, the ethical imperative, in the form of the Golden Rule, proves to be implicated in the very constitution of the other in his or her otherness. (shrink)

According to Tye's PANIC theory of consciousness, perceptual states of creatures which are related to a disjunction of external contents will fail to represent sensorily, and thereby fail to be conscious states. In this paper I argue that heat perception, a form of perception neglected in the recent literature, serves as a counterexample to Tye's radical externalist claim. Having laid out Tye's absent qualia scenario, the PANIC theory from which it derives and the case of heat perception as a counterexample, (...) I defend the putative counterexample against three possible responses: (1) that heat perception represents general (i.e. non-disjunctive) intrinsic properties of objects, (2) that heat perception represents the non-specific heat energy that is transferred between a subject's body and another body and (3) that heat perception exclusively represents heat properties of the subjects own body. (shrink)

This analysis shows Cantor's diagonal definition in his 1891 paper was not compatible with his horizontal enumeration of the infinite set M. The diagonal sequence was a counterfeit which he used to produce an apparent exclusion of a single sequence to prove the cardinality of M is greater than the cardinality of the set of integers N.

In Wollstonecraft’s early writings, she articulates the foundational theological and philosophical principles that would underpin her work throughout her career. One difference between her early and later work lies in the way that the values to which she refers are combined. Whereas Wollstonecraft at first appeals to the separate ideals of independence, equality, and virtue, from the 1790s onwards she integrates these into a characteristic republican framework that was in common use amongst dissenting theorists at the time. The set of (...) values on which Wollstonecraft draws, and the version of the republican framework that she develops, closely resemble those of Richard Price with whose work she was familiar. Examining the structural similarities between their respective models, I argue, gives us an insight into the systematic manner of aspects of Wollstonecraft’s own thought. It also allows us to see how Wollstonecraft goes beyond the republicanism of Price and others as she develops her own feminist solutions to the problems of structural domination. (shrink)

Freud, kendini Kopernik ve Darwin’in de dahil olduğu merkezsizleştirici düşünce hareketi içinde görmekteydi. Ünlü bir pasajında, psikanalizin, “egoya kendi evinin bile efendisi olmadığını, ancak aklında, bilinçten uzak bir biçimde olup bitenlerin kıt bilgisi ile yetinmesi gerektiğini kanıtlamaya çabaladığını” söyler. Kendimizin önemli olduğu hissi veya özdenetim duygumuz, gerçekten kendimize karşı şeffaf olduğumuz inancına mı dayanmaktadır? Bilinç dışının keşfi neden arzularımızın keşfine değersizlik eklemek zorundadır?Freud thought of himself as part of the same “decentering” movement of thought to which Copernicus and Darwin belonged. (...) In a famous passage, he says that psychoanalysis “seeks to prove to the ego that it is not even master in its own house, but must content itself with scanty information of what is going on unconsciously in its mind.” Does our sense of our importance, or our capacity for self-control, really depend on the belief that we are transparent to ourselves? Why should the discovery of the unconscious add humiliation to the discovery of the passions? (shrink)

Here I review the recent edited volume "Richard Kearney's Anatheistic Wager: Philosophy, Theology, Poetics.".

This book presents a selection of theoretical and applied texts of Richard Hare, as well as an appendix which includes several fundamental studies for the understanding of the ethics of 20th century.

Richard Wright gave a series of lectures in Europe from 1950 to 1956, collected in the following year in the volume, White Man, Listen! One dominant theme in all four essays is that expanding the moral imagination is centrally important in repairing our racism-benighted globe. What makes Wright’s version of this claim unique is his forthright admission that expanding the moral imagination necessarily involves pain and suffering. The best place to hear Wright in regard to the necessary pain of (...) expanding the moral imagination, I would argue, is his poetry collection, This Other World: Projections in the Haiku Manner. To wit, for Wright the necessary pain of expanding one’s moral imagination is the loneliness that results from delegating to others—in the etymological sense of “deputizing or committing”—one’s whiteness qua privilege or social capital. In conclusion, lonely delegation constitutes an imperative template from Wright regarding the painful expansion of our own moral imagination, in the service of social justice for economically oppressed communities of color across the globe. (shrink)

사회 세계 (MSW)를 만들기 에 자세히 언급하기 전에 m나는 먼저 철학 (설명 심리학)과 Searle (S)와 비트 겐슈타인 (W)의 작품에서 예시로 현대 심리학 연구와의 관계에 대한 몇 가지 의견을 제공 할 것입니다, 나는 이것이 행동에 Searle 또는 어떤 해설자를 배치하는 가장 좋은 방법이라고 생각하기 때문에, 적절한 관점에서. 그것은 크게 설명 심리학의이 두 천재에 의해 PNC, TLP, PI, OC, TARW 및 기타 책의 내 리뷰를 볼 도움이 될 것입니다. S는 TLP의 메커니즘으로 W의 선견지명 진술과 그의 후기 작업에서 그의 파괴에 대한 언급을하지 않습니다. (...) W, S는 행동의 이러한 기계적 견해의 주요 해체자가되었다, 그리고 가장 중요한 설명 심리학자 (철학자), 하지만 W가 그를 완전히 예상하고, 크게, 다른 사람을 수행 (하지만 W, 튜링과 AI에 프라우드 풋과 코플랜드의 많은 논문과 책을 참조하십시오). S의 작품은 W보다 훨씬 쉽게 따라할 수 있으며, 일부 전문 용어가 있지만 올바른 방향으로 접근하면 대부분 극적으로 분명합니다. 자세한 내용은 W S 및 기타 책에 대한 내 리뷰를 참조하십시오. 전반적으로, MSW는 작업의 S의 반세기에서 발생하는 Wittgenstein을 통해 많은 실질적인 발전의 좋은 요약이지만, 내 보기에, W는 여전히 그가 말하는 것을 파악하면 기본 심리학에 대한 타의 추종을 불허합니다 (내 리뷰 참조). 이상적으로, 그들은 함께 읽어야한다 : S1 / S2의 운영W의 기발한 예와 함께 설명 S2 / S3의 운영에 명확한 일관된 산문과 일반화에 대한 Searle, 그의 화려한 격언. 제가 훨씬 어렸을 때, 저는 그 일을 하는 책을 쓰곤 했습니다. 현대 의 두 시스템 보기에서인간의 행동에 대한 포괄적 인 최신 프레임 워크를 원하는 사람들은 내 책을 참조 할 수 있습니다'철학의 논리적 구조, 심리학, 민d와 루드비히 비트겐슈타인과 존 Searle의언어' 2nd ed (2019). 내 글의 더 많은 관심있는 사람들은 '이야기 원숭이를 볼 수 있습니다-철학, 심리학, 과학, 종교와 운명 행성에 정치 - 기사 및 리뷰 2006-2019 3 rd 에드 (2019) 및 21st 세기 4번째 에드 (2019) 및 기타에서 자살 유토피아 망상. (shrink)

Recalling Thomas Nagel’s discussion concerning the difficulties associated with developing a scientific explanation for the nature of experience, Nagel states that current reductionist attempts fail by filtering out any basis for consciousness and thus become meaningless since they are logically compatible with its absence. In this article we call into question the fundamental philosophy of the mind-brain identity hypothesis of Cognitive Theory: ‘What processes in the brain give rise to awareness?’ and the associated search for ‘neural correlates of consciousness’ (NCC). (...) The proper scientific manner of posing the query should simply be ‘What processes give rise to awareness?’. We begin to formalize the Eccles psychon and summarize one of fourteen empirical protocols to test this putative model. This requires a new science of Unified Field, UF Mechanics, entailing in terms of our current stage of development operationally completed forms of quantum theory, gravitation and cosmology arising from a unique derivation of the M-Theory (string theoretic) vacuum. Until now the quest for psychophysical bridging has typically been in the arena between brain and quantum geometry; and many have wondered if contemporary science is sufficient for the task. Nagel further asks ‘what would be left if one removed the viewpoint of the subjective observer’ and then suggests ‘that the remaining properties would be the physical processes themselves or states intrinsic to the experience of awareness’. We examine a new theoretical framework for introducing and experimentally testing the underlying physical cosmology of these noetic parameters. (shrink)

A synthetic glance about the basic outlines of Hare's Meta-ethics is offered in this paper to support the idea that Hume's law is still a productive resource for ethical studies. Hare accepted the emotivist premise that moral judgments do not, in the same way as ordinary statements do, state matters of fact that are either true or false, but denied that therefore they must be forms of exclamation. The essential character of moral discourse consisted, not, as the emotivists had held, (...) in its links with subjective attitudes, but with action; moral judgments were prescriptive, in that they expressed commitments to action on the part of the person uttering them, and at the same time their rationality was assured by their universalisability, i.e. their property of applying not merely to the person uttering them, but to all similar persons in similar circumstances. (shrink)

Propositional logics in general, considered as a set of sentences, can be undecidable even if they have “nice” representations, e.g., are given by a calculus. Even decidable propositional logics can be computationally complex (e.g., already intuitionistic logic is PSPACE-complete). On the other hand, finite-valued logics are computationally relatively simple—at worst NP. Moreover, finite-valued semantics are simple, and general methods for theorem proving exist. This raises the question to what extent and under what circumstances propositional logics represented in various ways can (...) be approximated by finite-valued logics. It is shown that the minimal m-valued logic for which a given calculus is strongly sound can be calculated. It is also investigated under which conditions propositional logics can be characterized as the intersection of (effectively given) sequences of finite-valued logics. (shrink)

mソーシャルワールド(MSW)の作るについて詳しくコメントする前に、私はまず、サール(S)とウィトゲンシュタイン(W)の作品に例示されている哲学(記述心理学)と現代心理学研究との関係についてコメントし ます。これは、記述心理学のこれらの2つの天才によってPNC、TLP、PI、OC、TARWおよび他の本の私のレビューを見るのに大いに役立ちます。 Sは、TLPのメカニズムとしてのWの優れた心の声明と、彼の後の作品でそれを破壊することに言及していません。W以来、Sはこれらの機械的な行動観の主要なデコンスであり、最も重要な記述心理学者(哲学者)であ るが、Wが彼をいかに完全に予想していたか、そして大きく他の人たちも(しかし、W、チューリング、AIのプラウドフットとコープランドの多くの論文や本を見る)を知らない。Sの仕事はWの仕事よりもはるかに簡単 で、専門用語はありますが、正しい方向からアプローチすればほとんど見事に明らかです。詳細については、W S やその他の書籍の私のレビューを参照してください。 全体として、MSWはSの半世紀の仕事に起因するヴィトゲンシュタインに対する多くの実質的な進歩の良い要約ですが、私の見解では、Wは彼が言っていることを理解すると、基本的な心理学のためにまだ不平等です(私 のレビューを参照)。理想的には、彼らは一緒に読む必要があります:S2 / S3の動作に関する明確な一貫した散文と一般化のためのサールは、S1 / S2の動作のWの厄介な例と彼の華麗な格言で示されています。もし私がずっと若かったら、まさにそれをやっている本を書くだろう。 現代の2つのシス・エムスの見解から人間の行動のための包括的な最新の枠組みを望む人は、私の著書「ルートヴィヒ・ヴィトゲンシュタインとジョン・サールの第2回(2019)における哲学、心理学、ミンと言語の論 理的構造」を参照することができます。私の著作の多くにご興味がある人は、運命の惑星における「話す猿--哲学、心理学、科学、宗教、政治―記事とレビュー2006-2019 第3回(2019)」と21世紀4日(2019年)の自殺ユートピア妄想st Century 4th ed (2019)などを見ることができます。 .

(Expected) adverse effects of the ‘ICT Revolution’ on work and opportunities for individuals to use and develop their capacities give a new impetus to the debate on the societal implications of technology and raise questions regarding the ‘responsibility’ of research and innovation (RRI) and the possibility of achieving ‘inclusive and sustainable society’. However, missing in this debate is an examination of a possible conflict between the quest for ‘inclusive and sustainable society’ and conventional economic principles guiding capital allocation (including the (...) funding of research and innovation). We propose that such conflict can be resolved by re-examining the nature and purpose of capital, and by recognising mainstream economics’ utilitarian foundations as an unduly restrictive subset of a wider Aristotelian understanding of choice. (shrink)

这是既惊人的,适合这个巨大的,行话满载(这本书真的需要一个词汇表!),大量的学术工作已成为畅销书在世界上的教育。一个人必须专心学习行话,然后翻阅551页的文本和238页的笔记。M,我们一次又一次地被告 知,这只是一个即将发生的事情的轮廓! 虽然他严厉批评了三个运动的过激行为,但从非常自由的精神观点来看,这是一种解构的、新时代神秘主义和后现代对宗教、哲学和行为科学的解释,没有最坏的德顿,下午和不结盟运动的行话,狂热的平均主义和反科学的反知 识主义。 他详细分析了哲学、心理学、社会学和宗教的各种世界观,揭露了哲学、心理学、社会学和宗教等不同世界观的致命减少缺陷,但如今他分析的大部分来源几乎毫无关系。 他们使用的术语和概念,已经过时的,当他研究和写作20年前。人们不得不浏览无数页的行话——关于哈贝马斯、康德、爱默生、荣格et.al。去珍珠 你得到一个了不起的样本,糟糕的写作,混乱和过时的想法和过时的行话。 如果一个人有一个良好的当前教育,读这本书(和大多数关于人类行为的写作)是双重痛苦的。 痛苦,因为它是如此的折磨和困惑,然后再次当你意识到它是多么简单与现代心理学和哲学。术语和想法是可怕的混乱和过时的(但在威尔伯自己的分析比在他的来源更不然)。 这本书和它的大部分来源是可能的心理文本,虽然大多数作者没有意识到这一点。它是关于人类行为和推理的,关于我们为什么以我们的方式思考和行动,以及将来我们如何改变。但是(就像直到最近所有的这类讨论一样),没 有一个解释是真正的解释,因此它们不能洞察人类的行为。没有人讨论所涉及的心理机制。这就像描述汽车是如何工作的by讨论方向盘和金属和油漆没有任何了解的发动机,燃料或传动系。事实上,像大多数老人们的行为解释 一样,这里引用的文字和威尔伯的文法通常更有趣,因为他们接受(和忽略!)作为解释,以及推理的种类,而不是实际内容。 如果一个人对哲学、认知和进化心理学有一套,大部分都是古老的。像几乎每个人都一样(学者和公众一样。g g.,看看我对丹奈特的自由进化和其他书籍的评论,他不明白宗教和伦理的基本知识——事实上所有的人类行为,都是被编程到我们的基因中。当他写许多书时,一场了解自己的革命正在发生,它经过他。 那些希望从现代两个系统的观点来看为人类行为建立一个全面的最新框架的人,可以查阅我的书《路德维希的哲学、心理学、Min d和语言的逻辑结构》维特根斯坦和约翰·西尔的《第二部》(2019年)。那些对我更多的作品感兴趣的人可能会看到《会说话的猴子——一个末日星球上的哲学、心理学、科学、宗教和政治——文章和评论2006-20 19年第3次(2019年)和自杀乌托邦幻想21篇世纪4日 (2019).

Contingency is the presence of non-actualized possibility in the world. Fatalism is a view of reality on which there is no contingency. Since it is contingency that permits agency, there has traditionally been much interest in contingency. This interest has long been embarrassed by the contention that simple and plausible assumptions about the world lead to fatalism. I begin with an Aristotelian argument as presented by Richard Taylor. Appreciation of this argument has been stultified by a question pertaining to (...) the source of necessity and possibility and a closely related one regarding the nature of metaphysics itself. Answering these questions reveals the crucial issue here, to wit, necessity and possibility in a temporal world. This issue is investigated through an important later criticism of Taylor by David Foster Wallace. Wallace’s critique is significant because it brings to the fore the pivotal notion for understanding contingency in a temporal world, that of synchronic possibility, the idea that incompatible states of affairs are possible at a single moment. This notion provides the basis of distinguishing two systematic accounts of truth, modality and time: two metaphysics of contingency. On one account, Taylor’s Aristotelian argument is straightforwardly valid and compelling; on the other, it is fallacious. In closing, I present reasons why the former account, supporting the Aristotelian views of time and truth, is correct and make some comments to ameliorate this conclusion. (shrink)

Depuis Gintis est un économiste senior et j’ai lu certains de ses livres précédents avec intérêt, je m’attendais à un peu plus de perspicacité dans le comportement. Malheureusement, il fait les mains mortes de la sélection de groupe et la phénoménologie dans les pièces maîtresses de ses théories du comportement, et cela invalide en grande partie le travail. Pire encore, puisqu’il montre un si mauvais jugement ici, il remet en question tout son travail précédent. La tentative de ressusciter la sélection (...) de groupe par ses amis à Harvard, Nowak et Wilson, il y a quelques années, c’était l’un des principaux scandales en biologie au cours de la dernière décennie, et j’ai raconté la triste histoire dans mon article 'Altruism, Jesus and the End of the World-how the Templeton Foundation bought a Harvard Professorship and attacked Evolution, Rationality and Civilization -- A review of E.O. Wilson 'The Social Conquest of Earth' (2012) et Nowak and Highfield 'SuperCooperators' (2012).' Contrairement à Nowak, Gintis ne semble pas être motivé par le fanatisme religieux, mais par le fort désir de générer une alternative aux sombres réalités de la nature humaine, facilitée par le manque (quasi universel) de compréhension de la biologie humaine fondamentale et le slateisme vierge des scientifiques comportementaux, d’autres universitaires et du grand public. Gintis attaque à juste titre (comme il l’a fait à maintes reprises) les économistes, les sociologues et d’autres scientifiques du comportement pour ne pas avoir un cadre cohérent pour décrire le comportement. Bien sûr, le cadre nécessaire pour comprendre le comportement est évolutif. Malheureusement, il ne parvient pas à en fournir un lui-même (selon ses nombreux critiques et je suis d’accord), et la tentative de greffer le cadavre pourri de la sélection de groupe sur toutes les théories économiques et psychologiques qu’il a généré dans ses décennies de travail, n’a fait qu’invalider tout son projet. Bien que Gintis fasse un vaillant effort pour comprendre et expliquer la génétique, comme Wilson et Nowak, il est loin d’être un expert, et comme eux, le calcul l’aveugle juste aux impossibilités biologiques et bien sûr c’est la norme en science. Comme Wittgenstein l’a noté sur la première page de la culture et de la valeur « Il n’y a pas de dénomination religieuse dans laquelle l’utilisation abusive des expressions métaphysiques a été responsable de tant de péchés qu’il l’a en mathématiques. » Il a toujours été clair que un gène qui provoque un comportement qui diminue sa propre fréquence ne peut pas persister, mais c’est le cœur de la notion de sélection de groupe. En outre, il a été bien connu et souvent démontré que la sélection de groupe réduit juste à la condition physique inclusive (sélection de parents), qui, comme Dawkins l’a noté, est juste un autre nom pour l’évolution par sélection naturelle. Comme Wilson, Gintis a travaillé dans cette arène pendant environ 50 ans et n’a toujours pas compris, mais après le scandale a éclaté, il ne m’a fallu que 3 jours pour trouver, lire et comprendre le travail professionnel le plus pertinent, comme détaillé dans mon article. Il est ahurissant de se rendre compte que Gintis et Wilson n’ont pas été en mesure d’y parvenir en près d’un demi-siècle. Je discute des erreurs de sélection de groupe et de phénoménologie qui sont la norme dans le milieu universitaire comme des cas spéciaux de l’échec quasi universel de comprendre la nature humaine qui détruisent l’Amérique et le monde. Ceux qui souhaitent un cadre complet à jour pour le comportement humain de la vue moderne de deux systemes peuvent consulter mon livre 'The Logical Structure of Philosophy, Psychology, Mind and Language in Ludwig Wittgenstein and John Searle' 2nd ed (2019). Ceux qui s’intéressent à plus de mes écrits peuvent voir «Talking Monkeys --Philosophie, Psychologie, Science, Religion et Politique sur une planète condamnée --Articles et revues 2006-2019 3e ed (2019) et Suicidal Utopian Delusions in the 21st Century 4th ed (2020) et autres. (shrink)

Antes de comentar en "La nueva ciencia de la mente", primero ofrezco algunos comentarios sobre filosofía y su relación con la investigación psicológica contemporánea como se ejemplifica en las obras de Searle (S), Wittgenstein (W), Hacker (H) et al. Ayudará a ver mis reseñas de PNC (Filosofía en un Nuevo Siglo), TLP, PI, OC, Making the Social World (MSW) y otros libros por y sobre estos genios, que proporcionan una descripción clara del comportamiento de orden superior, no se encuentra en (...) psicología ni filosofía, a la que me referiré como el marco de WS. Al igual que con tantos libros de filosofía, podríamos parar con el título. Como indican las citas y comentarios anteriores y en mis otras reseñas y los libros que cubren, hay razones convincentes para los problemas que enfrentamos al describir la psicología del orden superior considerado como conceptual y no científico. Esto debería ser cristalino para todos, pero la envidia de la ciencia y el olvido casi completo a WSH, etc. es un modo la! Pero como H señala anteriormente, los temas discutidos aquí son todo acerca de los juegos de idiomas y no tienen nada que ver con la ciencia. De hecho, como de costumbre, si uno traduce al inglés claro hay muy poco interés aquí, y ciertamente nada no dicho antes y mejor por WS, etc. innumerables veces desde los años 30 (véase, por ejemplo, The Blue and Brown Books de 1933- 35). No es de extrañar que no haga referencias significativas a ninguno de los libros o personas anteriores (¡la única referencia a S es un artículo de 1958!), aunque en mi opinión están en la parte superior de la lista de las principales figuras de la psicología descriptiva. En la p119 nos dice que la clave de todo esto es averiguar cómo "... un proceso cognitivo a nivel personal puede pertenecer a un sujeto representativo. Esta es la tarea de la segunda mitad del libro". Pero W hizo esto hace 80 años y ya que tenemos las explicaciones bellamente claras de WSH, H&M, etc., no tiene sentido torturarse con la prosa bastante sin rumbo y opaca que se desvía terminan en Sartre, Heidegger, Husserl y Frege, con un toque de ensalada de palabras posmodernista para buena medida. Un esfuerzo valiente en un tema interesante, pero en última instancia agotador e infructuoso. Aquellos que deseen un marco completo hasta la fecha para el comportamiento humano de la moderna dos sistemas punto de vista puede consultar mi libros Talking Monkeys 3ª ed (2019), Estructura Logica de Filosofia, Psicología, Mente y Lenguaje en Ludwig Wittgenstein y John Searle 2ª ed (2019), Suicidio pela Democracia 4ª ed (2019), La Estructura Logica del Comportamiento Humano (2019), The Logical Structure de la Conciencia (2019, Comprender las Conexiones entre Ciencia, Filosofía, Psicología, Religión, Política y Economía, Historia y Literatura (2019), Delirios Utópicos Suicidas en el siglo 21 5ª ed (2019), Observaciones sobre Imposibilidad, Incompletitud, Paraconsistencia, Indecidibilidad, Aleatoriedad, Computabilidad, Paradoja e Incertidumbre en Chaitin, Wittgenstein, Hofstadter, Wolpert, Doria, da Costa, Godel, Searle, Rodych Berto, Floyd, Moyal-Sharrock y Yanofsky(2019) y otros. (shrink)

In recent analytic literature on the Trinity we have seen a variety of "social" models of the Trinity. By contrast there are few "non-­‐social" models. One prominent "non-­‐social" view is Brian Leftow's "Latin Trinity." I argue that the name of Leftow's model is not sufficiently descriptive in light of diverse models within Latin speaking theology. Next, I develop a new "non-­‐social" model that is inspired by Richard of St. Victor's description of a person in conjunction with my appropriating insights (...) about indexicals from David Kaplan and John Perry. I point out that the copula in tokens of statements like, "I am the Father," is an ambiguous term and when used by a certain divine person a different proposition is affirmed. Central to this model is the claim that the copula bears the "is of identity" and the "is of numerical sameness without identity." Further, I show that Leftow's model employs two concepts of "person," a Lockean one and a Boethian one, and mine employs Richard of St. Victor's. I describe Leftow's model as a "hard non-­‐social" model and mine as a "soft non-­‐social" model that is nearer to some social models. I conclude that Leftow's model is not the lone candidate among "non-­‐social" models and that the variety of "non-­‐social" models has yet to be exhausted. (shrink)

In 1951 John Rawls expressed these convictions about the fundamental issues in metaethics: [T]he objectivity or the subjectivity of moral knowledge turns, not on the question whether ideal value entities exist or whether moral judgments are caused by emotions or whether there is a variety of moral codes the world over, but simply on the question: does there exist a reasonable method for validating and invalidating given or proposed moral rules and those decisions made on the basis of them? For (...) to say of scientific knowledge that it is objective is to say that the propositions expressed therein may be evidenced to be true by a reasonable and reliable method, that is, by the rules and procedures of what we may call "inductive logic"; and, similarly, to establish the objectivity of moral rules, and the decisions based upon them, we must exhibit the decision procedure, which can be shown to be both reasonable and reliable, at least in some cases, for deciding between moral rules and lines of conduct consequent to them.1 In this passage Rawls reconfigured the issue of moral objectivity and so reoriented the practice of metaethics from linguistic analysis to rational methodology. In so doing, his work has provided inspiration to philosophers as disparate in normative views as Thomas Nagel,2 Richard Brandt3, Alan Gewirth4, and David Gauthier.5 Rawls replaced the Moorean question, Do moral terms refer? with the Rawlsian question, Can moral judgments be the outcome of a rational and reliable procedure? He later gave a resoundingly positive answer to this question6 and later still, a more tentative one.7 Rawls' considered qualification of his earlier enthusiasm about the extent to which moral philosophy could be "part of the theory of rational choice"8 is a tribute to the seriousness with which he took his critics' objections. (shrink)

Is capitalism inherently predatory? Must there be winners and losers? Is public interest outdated and free-riding rational? Is consumer choice the same as self-determination? Must bargainers abandon the no-harm principle? Prisoners of Reason recalls that classical liberal capitalism exalted the no-harm principle. Although imperfect and exclusionary, modern liberalism recognized individual human dignity alongside individuals' responsibility to respect others. Neoliberalism, by contrast, views life as ceaseless struggle. Agents vie for scarce resources in antagonistic competition in which every individual seeks dominance. This (...) political theory is codified in non-cooperative game theory; the neoliberal citizen and consumer is the strategic rational actor. Rational choice justifies ends irrespective of means. Money becomes the medium of all value. Solidarity and good will are invalidated. Relationships are conducted on a quid pro quo basis. However, agents can freely opt out of this cynical race to the bottom by embracing a more expansive range of coherent action. (shrink)

Two decades ago, Rolf Landauer (1991) argued that “information is physical” and ought to have a role in the scientific analysis of reality comparable to that of matter, energy, space and time. This would also help to bridge the gap between biology and mathematics and physics. Although it can be argued that we are living in the ‘golden age’ of biology, both because of the great challenges posed by medicine and the environment and the significant advances that have been (...) made—especially in genetics and molecular and cell biology—we feel that information as an essential aspect of life has been neglected, or at least misunderstood. We therefore summon Maxwell’s Demon and its distant relative the ratchet, and apply these to biology. (shrink)

This chapter uncovers the complex negotiations for authority in various representations about futures of life which have been advanced by different branches of the sciences, and have culminated in the emerging concept of life as algorithm. It charts the historical shifts in expertise and representations of life, from naturalists, to mathematical modellers, and specialists in computation, and argues that physicists, game theorists, and economists now take a leading role in explaining and projecting futures of life. The chapter identifies Richard (...) Dawkins and Max Tegmark at the forefront of the concept of life as algorithm: the first inspired by game theory as a means to study evolution; the second proposing that a materialist basis of life could place humans and artificial intelligence on an equal footing. Through close reading of their respective texts, the chapter demonstrates that both thinkers consider life as an algorithm programmed to achieve success in survival and reproduction. (shrink)

Here I review Richard Kearney and Matthew Clemente's edited volume "The Art of Anatheism.".

After some years (or millennia) most works would no longer be considered eligible for "review." But an exception is called for, if the thrust of an older work is closely paralleled in a much more modern piece, as is the case between Plato's Theaetetus and Richard Rorty's acclaimed, and more recent volume, Philosophy and the Mirror of Nature. To fully understand and appreciate Rorty 's contribution to the subjects he raises, one must study his book in conjunction with Plato's (...) Theaetetus-where very similar issues have been discussed before. Both works concern a central question for philosophy: "What is knowledge?" The discussants in Plato's dialogue the Theaetetus, never do succeed in finding a satisfactory definition for knowledge, yet they at least realize to avoid thinking they know about the subject when, in fact, they lack that knowledge. Since Rorty explores some new (and not so new) ideas on these topics, Plato's discussants ask him a few questions. (Reprinted from original in Antioch Review). (shrink)

This review of Richard Tuck's Free Riding conveys Tuck's crucial distinction between the logic of collective action which fails due to the problem of causal negligibility, and free riding, which has been modeled as a Prisoner's Dilemma and involves casually impacting another actor in an adverse manner. Tuck also distinguishes the practice of voting which he argues neither fails due to the worry of causal negligibility or due to free riding; instead it represents a problem of achieving sufficiency of (...) votes representing a minimum winning coalition. This article clarifies how the problem of collective action resembles perfect free market competition which is defined to be characterized by a state in which no single agent can impact the price of a good. Similarly, in a large scale collective action, no single actor can have a causal impact on the outcome of the vast enterprise. This inability to make a difference due to the negligibility of each individual's causal power differentiates collective action and the tragedy of the commons from other social problems. (shrink)

These three volumes, entitled Essays On Values, bring together fortyone recent articles by researchers at the Nova Institute of Philosophy (IFILNOVA). They are a small sample of everything that, in the last four years, the Institute’s researchers have published, in English, in indexed journals and collections of essays with peer review. As a whole, they reflect very well the research work that is done at IFILNOVA. Section I. of Volume 1 gathers six articles that deal directly with the question “what (...) are values?”, the question that guides all the work of the institute’s different laboratories and research groups. The first article, by Susana Cadilha and Vítor Guerreiro, results from work developed in the Laboratory of Ethics and Political Philosophy (EPLab); the second, by João Constâncio, from the Lisbon Nietzsche Group; the third, by Alexandra Dias Fortes, from the Lisbon Wittgenstein Group; the third and fifth, by Nuno Fonseca, and Maria Filomena Molder, from the Aesthetics and Philosophy of Art Group of the Laboratory of Culture and Value (CultureLab); the last, by Erich H. Rast, from the Philosophy of Language and Argumentation Theory Group and the Lisbon Mind, Cognition & Knowledge Group of the Laboratory of Argumentation, Cognition, and Language (ArgLab). Section II. brings together three articles by members of the Lisbon Nietzsche Group. Since 2010, the Lisbon Nietzsche Group has completed several funded projects, and has established itself as a leading international research group on Nietzsche’s thought. The three articles demonstrate the crucial importance of the question of values in Nietzsche’s work, always thought from the perspective of the possibility of a “transvaluation of all values”. Maria João Mayer Branco’s article focuses on the value of introspection, and how Nietzsche anticipates Wittgenstein’s “expressivist” view of the “the Peculiar Grammar of the Word ‘I’” and the impossibility of private languages. Marta Faustino’s article considers the theme of affirmation and the value of life through the interpretation of Nietzsche’s reflection on truthfulness, intellectual honesty and courage in the light of Michel Foucault’s work on parrhesia. Pietro Gori’s article studies how Nietzsche creates a new anthropological ideal based on his enquiry into the values of the “good European”. The area of Wittgenstein studies has had a strong influence on the institute since the time when it was a philosophy of language institute. The Wittgensteinian distinction between facts and values was decisive in defining the question of values as the central issue of IFILNOVA’s research project, replacing the focus on philosophy of language. More recently, the focus of research at the Lisbon Wittgenstein Group has been on epistemic values, in particular in their connection with the question of religious belief. In Section III., Nuno Venturinha’s article examines, in the light of an epistemological standpoint, the way Wittgenstein thinks about the possibility of translation. Robert Vinten’s article argues that Wittgenstein’s thought contains elements for a critique of the concept of justice and of the liberal political visions of both Richard Rorty and Chantal Mouffe, despite the fact that both have drawn inspiration from Wittgenstein. Benedetta Zavatta’s article questions the value of mythology by thinking of it as a disease of language – not only in Wittgenstein, but also in a whole philosophical tradition that preceded him. The existence of a research group in ancient philosophy is a recent but very promising development in the life of IFILNOVA. Section IV. includes two articles by members of the group. Paulo Alexandre Lima’s article considers the critique of misology and the value of discourse in Plato’s Phaedo. Hélder Telo’s article examines the pedagogical and protreptic value of imperfection in Plato’s work. (shrink)

Ethics of Richard M. Hare is widely considered as a classical example of the strong internalistic theory of motivation: he is thought to believe that having a moral motive is a sufficient condition to act accordingly. However, strong internalism has difficulties with explaining the phenomenon of acrasia and amoralism. For this reason some critics charge him with developing a false theory of moral motivation. In the article I present Hare's answer to these questions by dividing the discussion about motivation (...) into three levels: semantical, epistemological, and ontological. I also explain his concept of internal motivation and argue that his theory, contrary to what his critics assume, may be called a weak motivational internalism. (shrink)

Tarihte herhalde çok az soru Tanrı’nın varlığı sorusu kadar sık sorulmuş, çok yanıtlanmış ve verilen birbirinden farklı onca yanıta rağmen kesin bir sonuca ulaştırılamayıp tartışılmaya devam etmiştir. Yine de geçmişe dönüp baktığımızda bu soruya verilen farklı yanıtların farklı uygarlıkların inşa edilmesine, bazılarının yıkılmasına, acımasız çatışmalara ve her şeye rağmen kucaklaşmalara da vesile olduğunu görüyoruz. Tanrı var mı? Varsa onu nasıl bilebiliriz? Tanrı yoksa her şey mubah mı? İnsan aklı ilahi olanı kavrayabilir mi? Tanrı’nın varlığı ahlaklı olmanın şartı mı? Evren akıllı (...) bir tasarımcının imzasını taşıyor mu? Bu kitapta felsefeci William David Beck, bu sorulara tarihte verilen yanıtları ve bu konudaki tartışmaları ele alarak meselenin genel ve tarihsel bir tablosunu bize sunuyor. Platon, Aristoteles, Marcus Aurelius gibi Eski Yunan ve Roma düşünürlerinden Anselmus, Thomas Aquinas, Augustinus ve Yahudi-Hıristiyan geleneğine, Doğu’nun bilgelerine, İbni Rüşd, Fârâbî ve Gazzâlî gibi İslam düşünürlerinden Alvin Plantinga, Graham Oppy, Sam Harris, Richard Dawkins, Max Tegmark gibi Batılı modern ilahiyatçılara, bilim insanlarına ve Yeni Ateizm hareketine kadar uzanan bir çizgide “Tanrı var mı?” sorusuna verilen çeşitli yanıtları ve bu yanıtlara sunulan akılcı gerekçeleri ortaya koyarak soruya felsefece bir yanıt vermenin nasıl bir iş olduğunu da gösteriyor. (shrink)

The Warner Books back cover proclaims: In the tradition of Oliver Sachʼs [sic] bestselling *The Man Who Mistook His Wife for a Hat...* The manner and misspellingsignify that Cytowic himself had nothing to do with such publishing hucksterism. However, one thing is clear upon reading this book: Richard Cytowic, M.D., is no Oliver Sacks. Though, as will be seen, there is much in here to recommend itself, his stilted reproduction of conversations which or may not have taken place and (...) his CreativeFiction 100 characterizations (i.e., Dr. Wood's continual inhalation of smoke or food) strike the experienced reader as painfully contrived, as though Cytowic were doing hislevel best to imitate Sacks and reach that always-elusive wider audience. (shrink)

There are some further responses I have to Mary Beard on the relationship between Sir James Frazer’s The Golden Bough and British colonialism: her claim that it provided an image of the empire as a whole. The paper contains two objections, very minor ones perhaps, and some highly speculatively defences. But I find the defences difficult to present in the traditional manner, so I have written the responses as a pastiche imitating a widely read European writer.

This is a response to Richard M. Gale’s review of my book God, the Best, and Evil, Clarendon Press 2008. The review was published on-line in May 2009, in Notre Dame Philosophical Reviews.

A new advanced systems theory concerning the emergent nature of the Social, Consciousness, and Life based on Mathematics and Physical Analogies is presented. This meta-theory concerns the distance between the emergent levels of these phenomena and their ultra-efficacious nature. The theory is based on the distinction between Systems and Meta-systems (organized Openscape environments). We first realize that we can understand the difference between the System and the Meta-system in terms of the relationship between a ‘Whole greater than the sum of (...) the parts’ and a ‘Whole less than the sum of its parts’, i.e., a whole full of holes (like a sponge) that provide niches for systems in the environment. Once we understand this distinction and clarify the nature of the unusual organization of the Meta-system, then it is possible to understand that there is a third possibility which is a whole exactly equal to the sum of its parts that is only supervenient like perfect numbers. In fact, there are three kinds of Special System corresponding to the perfect, amicable, and sociable aliquot numbers. These are all equal to the sum of their parts but with different degrees of differing and deferring in what Jacques Derrida calls “differance”. All other numbers are either excessive (systemic) or deficient (metasystemic) in this regard. The Special Systems are based on various mathematical analogies and some physical analogies. But the most important of the mathematical analogies are the hypercomplex algebras, which include the Complex Numbers, Quaternions, and Octonions, with the Sedenions corresponding to the Emergent Meta-system. However, other analogies are the Hopf fibrations between hyperspheres of various dimensions, nonorientable surfaces, soliton solutions, etc. These Special Systems have a long history within the tradition since they can be traced back to the imaginary cities of Plato. The Emergent Meta-system is a higher order global structure that includes the System with the three Special Systems as a cycle. An example of this from our tradition is in the Monadology of Gottfried Wilhelm von Leibniz. There is a conjunctive relationship between the System schema and the Special Systems that produce the Meta-system schema cycle. The Special Systems are a meta-model for the relationship between the emergent levels of Consciousness (Dissipative Ordering based on the theory of negative entropy of Prigogine), Living (Autopoietic Symbiotic based on the theory of Maturana and Varela), and Social (Reflexive based on the theory of John O’Malley and Barry Sandywell). These different special systems are related to the various existenitals identified by Martin Heidegger in Being and Time and various temporal reference frames identified by Richard M. Pico. We also relate the special systems to morphodynamic and teleodynamic systems of Terrence Deacon in Incomplete Nature to which we add sociodynamic systems to complete the series of Special Systems. (shrink)

B a c k g r o u n d . The article is devoted to the Minnemystik of Hadewijch of Brabant in the XIII century. It deals with the genesis of Hadewijch's concept of Minne in its relation to the monastic Cistercian mysticism of Bernard of Clairvaux, William of Saint-Thierry in the XII century and Beatrice of Nazareth in the XIII century. It also considers the conception of theologist and philosopher Richard of Saint-Victor in the XII century. Considering (...) the existing advances of researchers on Hadewijch's Minnemystik, since the XX century, this investigation especially focuses on the primary role of the secular tradition of minnesingers and trobairitz of the mid-XIII century in her texts. M e t h o d s . The main method of the article is a comparative analysis. It is used to find the common meaning of Minne in two traditions: secular and religious minnesingers. The historical-philosophical approach allows us to demonstrate the conceptual link between monastic theology in the XII–XIII centuries and Hadewijch's beguinal Minnemystik. R e s u l t s . The article sheds light on Hadewijch's concept of the Minne and stresses the primary role of the secular and religious conceptions of predecessors and contemporaries in Hadewijch's Minnemystik. C o n c l u s i o n . The author underlines that Hadewijch's concept of Minne comes from the secular tradition of minnesingers and, especially, trobairitz. It also derives from the XII-century male and female mystic theology, which follows Augustine. Thus, the concept of the Minne is deeply connected with the notion of Amor and the tradition of "courtly love", and with Caritas and the tradition of "pure love". K e y w o r d s : Hadewijch's concept of the Minne, Caritas, trobairitz, minnesingers, troubadours, Minnemystik, Unio Mystica, William of Saint-Thierry, Beatrice of Nazareth, Richard of Saint-Victor, Bernard of Clairvaux. (shrink)

FISIOLOGIA DA REPRODUÇÃO BOVINA -/- 3 – GESTAÇÃO -/- -/- INTRODUÇÃO -/- -/- O estabelecimento da gestação é o objetivo fundamental dos programas reprodutivos. Após a fertilização, o zigoto se divide e dá origem a embriões de duas, quatro, oito, dezesseis células, e no sétimo dia o embrião tem mais de 80 células. Entre os dias 16 e 18 do ciclo estral, o embrião se alonga e atinge 15 cm de comprimento. O estabelecimento da gestação depende da supressão da secreção (...) de PGF2α pelo embrião, que é realizada por meio da secreção de interferon-τ. Em vacas leiteiras, uma alta proporção de embriões morre antes do reconhecimento materno da gravidez. -/- Para evitar perdas embrionárias, é importante conhecer a fisiologia da gestação. Este capítulo descreve os principais processos fisiológicos que levam ao estabelecimento e manutenção da gestação e ao manejo da vaca prenhe. -/- -/- 3.1 Transporte de gametas -/- -/- Os gametas, óvulo e esperma, são definidos como células germinativas maduras que possuem um número haploide (n = 23) de cromossomos que, quando unidos, dão origem a um novo indivíduo geneticamente diferente de ambos os pais. -/- -/- 3.1.1 Transporte dos espermatozoides -/- -/- Os espermatozoides obtidos diretamente do testículo são funcionalmente imaturos, incapazes de fertilizar o óvulo. Durante sua permanência no epidídimo, os espermatozoides sofrem alterações na morfologia, mobilidade e metabolismo, o que lhes dá a capacidade de fertilização. No entanto, eles terão que passar algum tempo no trato genital feminino para que adquiram o estado ideal para fertilizar; processo conhecido como capacitação. -/- Durante a monta natural, a ejaculação ocorre na vagina e são depositados cerca de 5 x 109 de espermatozoides (volume ejaculado de três a cinco ml e concentração espermática de 1 x 109 a 1,2 x 109 por ml) suspensos no plasma seminal, este é basicamente constituído pelas secreções das vesículas seminais e da próstata. Após a ejaculação, o transporte dos espermatozoides é favorecido pelas contrações uterinas e vaginais que ocorrem durante e após a relação sexual. Nos primeiros minutos após a cópula, os espermatozoides já podem ser encontrados no oviduto, o que se deve às contrações do trato genital. Durante o transporte dos espermatozoides, a mobilidade individual é importante, já que apenas os espermatozoides com essa capacidade chegam ao local da fertilização. -/- O primeiro local para o estabelecimento de uma população de espermatozoides é a cérvix do útero, principalmente nas criptas, onde permanecem protegidos da fagocitose. É importante observar que apenas os espermatozoides móveis permanecem nas criptas; aqueles que estão mortos ou sem movimento são eliminados pelos fagócitos ou pelo movimento do muco cervical em direção a vagina. Embora uma população temporária de espermatozoides seja estabelecida no colo do útero, o reservatório funcional de espermatozoides está localizado na região distal do istmo. -/- As características do muco cervical são importantes para o transporte dos espermatozoides; assim, durante o estro e a ovulação, o muco fica mais aquoso, o que favorece a migração dos espermatozoides, enquanto na fase lútea o muco torna-se mais viscoso, dificultando sua movimentação. -/- Já no útero, o transporte de espermatozoides depende principalmente das contrações uterinas. Aqui, os espermatozoides ficam suspensos nas secreções uterinas, cuja função é promover sua viabilidade e transporte. As secreções uterinas contêm fagócitos que removem os espermatozoides mortos e imóveis, embora os espermatozoides normais também sejam removidos por esse meio. Algumas substâncias, como prostaglandinas e ocitocina, promovem o transporte. -/- O oviduto desempenha um papel muito importante no transporte e maturação dos gametas, bem como na fertilização e desenvolvimento embrionário inicial. As características das secreções do oviduto variam de acordo com a região do oviduto e o estágio do ciclo estral. Uma vez que os espermatozoides atingem o oviduto, eles são distribuídos em dois lugares. Alguns espermatozoides são imediatamente transportados para a região da ampola; esses são os primeiros que encontram o ovócito, mas sua capacidade de fertilização é limitada. O outro local de distribuição é a região caudal do istmo; aqui eles permanecem até que a ovulação seja iminente. Para que a fertilização ocorra, é necessário que o espermatozoide se estabeleça neste local por um período de seis a oito horas, antes da ovulação. Uma a duas horas, antes da ovulação, um movimento ativo do espermatozoide é observado em direção à região da ampola. -/- No oviduto, o transporte de espermatozoides depende de seu movimento, do fluido ovidutal e das contrações musculares. É comum que alguns espermatozoides continuem seu movimento e saiam pela fímbria. A viabilidade do espermatozoide de uma ejaculação varia de 24 a 48 horas. -/- -/- 3.1.2 Transporte do ovócito -/- -/- A ovulação é o processo pelo qual o ovócito é liberado. Este evento é desencadeado pela secreção de LH conhecida como pico de LH ovulatório ou pré-ovulatório. -/- Devido ao efeito de LH o cúmulos descola-se da parede folicular e começa a observar-se um adelgaçamento em uma pequena área da parede folicular, causada pela isquemia e pela ação de enzimas proteolíticas. Mais tarde, nesta área, uma pequena vesícula protuberante (estigma) se forma e eventualmente se quebra. Depois que o estigma é quebrado, o cúmulos que contém o ovócito junto com as células da granulosa. O ovócito é capturado pela fimbria; processo apoiado por movimentos dos cílios da mucosa e por contrações das pregas desta estrutura. Assim que o oócito é capturado, ele é transportado para a ampola. -/- 3.8 Manejo da vaca seca -/- -/- Em programas de manejo anteriores, a vaca seca recebia comida de pior qualidade e permanecia no esquecimento até o parto ocorrer. No entanto, os resultados dos estudos mostram que o período de seca é decisivo para que a vaca atinja um nível ótimo de produção e tenha um bom desempenho reprodutivo pós-parto. Por outro lado, o manejo correto no período seco reduz a incidência de doenças metabólicas no puerpério. O objetivo do período de seca é oferecer um descanso à vaca antes do parto, durante o qual o tecido mamário se regenera, o feto atinge seu crescimento máximo e a vaca atinge uma condição corporal adequada para enfrentar uma nova lactação. A duração recomendada do período de seca é de seis a oito semanas (60 dias). A involução do tecido da glândula mamária leva de duas a três semanas e um período semelhante é necessário para reiniciar a síntese do leite antes do parto. Assim, um período de seca de 60 dias é suficiente; entretanto, a duração desse período é questionada e tempos mais curtos foram propostos. Provavelmente, nos próximos anos, mais informações estarão disponíveis para apoiar a redução do período de seca. -/- Em termos de produção, o objetivo do manejo durante o período de seca é levar a vaca ao pico de lactação cinco a seis semanas após o parto, com produção máxima de leite. Estima-se que para cada kg de leite que aumenta no pico da lactação, ocorre um aumento de 120 kg ao longo da lactação. Para atingir este objetivo é necessário que a vaca tenha um consumo adequado de matéria seca após o parto; porém, três semanas antes do parto, a vaca reduz seu consumo em até 30%, para o qual é necessário estabelecer um manejo eficaz para promover um alto consumo de matéria seca durante a parte final do período de seca e durante as três primeiras semanas pós-parto (período de transição: três semanas antes e três após o parto). -/- A falta de capacidade de consumir as necessidades de matéria seca após o parto obriga a vaca a mobilizar suas reservas de gordura. Praticamente todas as vacas após o parto mobilizam suas reservas de gordura e perdem a condição corporal. A mobilização da gordura corporal causa degeneração gordurosa do fígado e é responsável por distúrbios metabólicos e retardo da atividade ovariana pós-parto. O grau de degeneração da gordura está relacionado à magnitude da mobilização da gordura corporal, que é diretamente dependente da capacidade de consumir matéria seca. Dessa forma, vacas com alto consumo de matéria seca no pós-parto, mobilizam menos gordura e, portanto, o dano ao fígado é menor. -/- O período de secagem é dividido em duas partes, a primeira compreende desde a secagem até duas semanas antes do parto; a segunda parte inclui as últimas duas semanas de gestação e é conhecida como período de desafio. -/- O período de desafio é decisivo para o desempenho produtivo e reprodutivo. Durante este período, uma dieta semelhante em ingredientes e forma deve ser oferecida à dieta que farão após o parto. Para facilitar esse manejo, as vacas deste grupo devem ser separadas do restante das vacas secas. -/- No período de seca, atenção especial deve ser dada para que as vacas não alcancem escores de condição corporal de quatro ou mais, uma vez que o excesso de gordura causa problemas metabólicos durante o puerpério, que afetam negativamente o comprometimento uterino e início da atividade ovariana pós-parto (figura 8). -/- -/- -/- Figura 8: Estágios fisiológicos e reprodutivos da vaca leiteira. Período de espera voluntário (PVE). -/- -/- 3.9 O período de transição -/- -/- O período de transição na vaca leiteira é três semanas antes e três após o parto (também conhecido como periparto). Nos últimos anos, esse tema tem merecido muitas pesquisas, pois o que for bem ou mal feito durante ele terá impacto na eficiência reprodutiva e na produção de leite. Durante o período de transição, a glândula mamária se prepara para a lactogênese, o feto cresce exponencialmente, a resposta imune é suprimida e o consumo de matéria seca diminui; além disso, o rúmen deve se adaptar à dieta recebida pelas vacas in natura (primeiras três semanas pós-parto), dieta caracterizada por alto teor de energia na forma de grãos. -/- Muitos distúrbios que se manifestam nas duas primeiras semanas pós-parto (hipocalcemia clínica e subclínica, cetose, retenção placentária, prolapso uterino, metrite, mastite, deslocamento do abomaso etc.), como os que se apresentam posteriormente (laminite, cistos ovarianos , endometrite e anestro) têm sua origem nos erros cometidos durante o período de transição. Em grande parte, os problemas estão relacionados à diminuição do consumo de matéria seca durante o período de transição; assim, o consumo diminui cerca de 30% durante as últimas três semanas de gestação, mas a maior parte da redução ocorre cinco a sete dias antes do parto. O manejo correto do período de transição tem como objetivo manter a normocalcemia, fortalecer o sistema imunológico, adaptar o rúmen a uma dieta rica em energia e aumentar a ingestão de matéria seca. Algumas recomendações gerais de manejo durante o período de transição são: separar as novilhas das vacas, ter comedouro suficiente para todos os animais, ter as mesmas características dos comedouros de vacas frescas e a dieta deve estar disponível 24 horas por dia (figuras 9 e 10). -/- -/- -/- Figura 10: O desempenho produtivo e reprodutivo das vacas depende em grande parte da condição corporal no momento do parto. Nesta fotografia são mostradas vacas recém-paridas, com uma condição corporal ideal (3,5). -/- Figura 9: Vacas no curral do desafio. Recomenda-se separar as novilhas das vacas, ter espaço suficiente com comedouro e a dieta deve estar disponível 24 horas por dia. -/- -/- RESUMO -/- -/- Cerca de 5 bilhões de espermatozoides são depositados em a genitália da vaca durante a cópula. Os espermatozoides devem permanecer no istmo e na região da junção útero-tubária por seis a oito horas antes da ovulação para obter uma alta taxa de fertilização. A viabilidade dos espermatozoides no útero é de 24 a 48 horas. A polispermia é efetivamente bloqueada nas primeiras 10 horas após a ovulação. Os blastômeros de embriões de duas, quatro e oito células são pluripotentes. A eclosão do embrião ocorre no oitavo dia. O tempo que o embrião leva para chegar ao útero é de três a quatro dias. Entre os dias 16 e 18 do ciclo, o embrião produz interferon-t, para bloquear a secreção de PGF2α. Entre os dias 17 e 18, o embrião se fixa ao endométrio. A medição da progesterona entre os dias 20-24 pós-infecção é 100% precisa na identificação de vacas não gestantes. A vaca deve atingir seu pico de lactação entre cinco e seis semanas após o parto. Para cada kg de leite que é aumentado no pico da lactação, um aumento de 120 kg é alcançado na lactação de 305 dias. Três semanas antes do parto, a vaca reduz seu consumo em até 30%. O período de transição inclui três semanas antes e três após o parto. As vacas ao parto não devem ter mais do que quatro pontos de condição corporal. A proporção de vacas secas deve ser de 15% (12,5% de vacas secas e 2,5% de novilhas). -/- -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- -/- BEARDEN, Henry Joe et al. Applied animal reproduction. Reston Publishing Company, Inc., 1984. -/- Endocrinologia da Reprodução Animal. Recife, UFRPE, 2020. -/- Fisiologia da Reprodução Animal: Fecundação e Gestação. Recife: UFRPE, 2020. -/- HAFEZ, Elsayed Saad Eldin; HAFEZ, Bahaa. Reprodução animal. São Paulo: Manole, 2004. -/- HIDALGO, Galina et al. Reproducción de animales domésticos. México: Limusa, 2008. -/- HOLY, Lubos; MARTÍNEZ JÚSTIZ, G. Colab. Biología de la reproducción bovina. Havana: Revolucionária, 1975. -/- HOPPER, Richard M. (Ed.). Bovine reproduction. John Wiley & Sons, 2014. -/- LEBLANC, Stephen. Monitoring metabolic health of dairy cattle in the transition period. Journal of reproduction and Development, v. 56, n. S, p. S29-S35, 2010. -/- SARTORI, Roberto; BASTOS, Michele R.; WILTBANK, Milo C. Factors affecting fertilisation and early embryo quality in single-and superovulated dairy cattle. Reproduction, Fertility and Development, v. 22, n. 1, p. 151-158, 2009. -/- SENGER, Phillip L. et al. Pathways to pregnancy and parturition. Current Conceptions, Inc., 1615 NE Eastgate Blvd., 1997. -/- VIVEIROS, Ana Tereza de Mendonça. Fisiologia da reprodução de bovinos. Lavras: UFLA, p. 62, 1997. (shrink)